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Reasoning that the enzymes encoded by these genes could be responsible for the utilization of l-carnitine and its conversion to BB (Figure 7C), we used comparative genomics tools to identify 3 other organisms that contain the caiTABCDE gene operon (Supplemental Figure 5), and assessed their ability to consume l-carnitine and produce BB (Figure 8)

Animal models are indispensable for mechanistic exploration but cannot fully replicate the long-term, multifactorial progression of human neurodegenerative diseases

22293030, 22293032, 21535005, 20921062, 20621502 and 20025311) and the National Basic Research Program of China (973 Program, 2006CB933100 and 2011CB933600)

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