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For all these reasons, COPD remains a major worldwide health problem and global burden of disease studies have estimated COPD as the third leading cause of death worldwide [4]

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Abnormal coagulation: the role of microclots and inflammagens in circulation that cause pathological clotting It has been hypothesised that hypercoagulation plays a significant role in ME/CFS (349351), but there are still discrepancies between studies (352)

For example, 2859% of patients with FMS that develop IBS, and 3277% of patients diagnosed with the diagnosis of IBS develop FMS during the course of their illness, with a relative risk increase of approximately 1.54-fold