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10.1096/fj.202000669rr 76 LemireJ.MaillouxR.DarwichR.AugerC.AppannaV

Dysfunctional mitochondria in age-related neurodegeneration: utility of melatonin as an antioxidant treatment

2 Ferroptosis and its history Dixon and his colleagues first discovered ferroptosis in 2012 in cancer cells carrying mutations in the renin-angiotensin system (RAS), which is a type of abnormal suicidal cell fate regulated by iron-catalyzed reaction (Dixon et al., 2012) (Figure 1)