Acetylcholinesterase Active Site Mighty Model© ACHE Active Site Mighty Model Set:ACHE Active Site Mighty Model Set of 6 Clips grip the Modeling Tie

Acetylcholinesterase Active Site Mighty Model© ACHE Active Site Mighty Model Set:ACHE Active Site Mighty Model Set of 6 Clips grip the Modeling TieMany common insecticides work by targeting the enzyme acetylcholinesterase. This fold out model makes the enzymes crowded active site more approachable, as it lets students experiment with a magnet docked substrate (acetylcholine), inhibitor (insecticide), and mutant side chain (serine). Students can immediately intuit how one mutation, Gly119Ser, blocks the insecticide from fitting in the active site. Through modeling, your students will learn: The

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