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PNPO mutations are treated with high doses of P5P (active form), thus providing the active form of B6 without the need for conversion

Glassman PM, Muzykantov VR (2019) Pharmacokinetic and pharmacodynamic properties of drug delivery systems

Patients require lifelong hydroxocobalamin injections, typically 1mg every three months following an initial loading regimen (or every two months if there was neurological involvement)

To date, more than 20 different AFs have been identified with moderate to high toxicity effects on the human body ( Figure 1 The laboratory analysis of AFs identified several metabolized AFs derivatives that rarely found in the human body ( Fusarium species should be taken into account because of their potential to outbreak and influence the future food safety and security ( The upcoming GCC and future AFs contamination risks The GCC is becoming a serious concern, and being the future driver of food safety and security ( Studies disclosed that GCC induces the occurrence of plant fungal pathogens by providing appropriate environmental requirements for their growth and development ( The GCC might support the growth and development of APF in crop production sites ( Different strategies have been applied to address the GCC in advanced and developing countries (59)