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3) Muscle tissue-specific mechanisms have yet to be fully elucidated, particularly whether the IMF differences between breast muscle and leg muscle stem from distinct adipogenic precursor cell differentiation trajectories or specific metabolic pathways

Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

A similar mutation at an identical position in the second zinc cluster of the glucocorticoid receptor DNA-binding domain has been created to discriminate between dimerization/DNA binding of the glucocorticoid receptor and protein-protein interactions with other transcription factors such as the AP-1 transcription complex (275)