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For the purpose of this discussion, we will focus on substances that are commonly referred to as gateway drugs: caffeine alcohol tobacco marijuana Caffeine Image 4.2 Hot Coffee in a White Mug Surrounded by Coffee Beans on a Wood Table History and Background Caffeine is a bitter substance that occurs naturally in more than 60 plants, including coffee beans, tea leaves, kola nuts (used to flavor soft-drink colas), and cacao pods (used to make chocolate products)

thus it has been suggested that non-nicotine components of tobacco smoke decrease brain levels of monoamine oxidase A and B which possibly change sensitivity to the actions of nicotine and/or exert independent behavioural effects (Eid et al

But they are far from optimized designs in many ways

Individuals with mental health conditions are more likely to report smoking and smoking in greater amounts