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[DOI] [PubMed] [Google Scholar] 72.Spiller HA, Winter ML, Klein-Schwartz W, Bangh SA

Dysfunction of the microbiota leads to decreased BA activity, reducing unconjugated BA and secondary BA production, weakening FXR activity, and exacerbating cirrhosis through various pathways: (1) In hepatocytes, FXR interacts with nuclear receptors such as peroxisome proliferator-activated receptors (PPAR)- and liver X receptor (LXR) to form heterodimers, regulating downstream target gene expression

Furthermore, these findings should be replicated in greater cohort studies, particularly in other food allergies, to determine whether the observed mechanisms are consistent and can be generalized

Because of its reputation for supporting energy, skin clarity, and liver health, many people reach for glutathione supplements to keep their levels topped up