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Additionally, HDP, encompassing pre-eclampsia and gestational hypertension, occurred with a prevalence of 33.3% in those with UIC 250 g/L compared to 4.3% in those with 150-249 g/L (24)

Mechanistically, HIF-1 binds to hypoxia-response elements (HREs) within the PD-L1 promoter, enhancing its expression in both tumor cells and immunosuppressive myeloid populations such as macrophages and MDSCs, thereby reinforcing an immune-resistant TME [329]

Of these, TRIMs 13, 16, 58, and 62 have reduced levels of expression, whereas the majority of TRIMs associated with lung cancer are increased in expression

41 The consequences of iron overload may be diverse beyond hemochromatosis