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Chronic inflammation has been identified as a central feature in many patients, linking immune dysregulation to symptomatology such as fatigue and cognitive impairments

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Additionally, pharmacological blockade of mGluR5 with MTEP (an mGluR5 antagonist) has been found to increase 5-HT release, further emphasizing the interconnected roles of these receptors

Itching and mild swelling are among the most frequently reported injection-site reactions, affecting roughly 510% of patients during their first few weeks of treatment