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The present study supports these findings, as we show that an increased kynurenine/tryptophan (Kyn/Trp) ratio, a well-established marker of inflammation [63, 78, 79], correlates with manifest disease

These features are also of great relevance for the accumulation in the host lysosome (Trapp et al., 2008) and parasite mitochondria (Talukdar et al., 2021)