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The search strategy employed Boolean operators (e.g., AND, OR) to combine terms for natural flavonoid metabolites (e.g., quercetin, baicalin, epigallocatechin-3-gallate [EGCG]) with keywords related to AD and its underlying mechanisms, including skin barrier dysfunction, immune dysregulation, chemokine imbalance, pruritogenic signaling, microbial dysbiosis, programmed cell death, oxidative stress, and drug delivery

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IEC suspensions were snap-frozen in lysis buffer and stored at 80 C until GPX4 enzymatic activity testing (see section GPX4 enzymatic activity assay) or protein analysis by western blot (see section Immunoblot)

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