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doi: 10.1016/j.canlet.2017.03.008

By assisting in the transport of fatty acids for energy production, L-Carnitine may help individuals maximize the benefits of a healthy diet and regular exercise program

however, human safety profiles remain undefined

Graphical Abstract The graphical abstract depicts an overview of the pathways involved in the emergence of morphine-related tolerance and dependence including NMDA, Nitric oxide, and PPAR, as well as behavioural sensitization along with present and future innovative treatment strategies including stem cell therapy that have been discussed in the current manuscript