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Lenton in the context of environmental systems defines tipping points as conditions or situations, where a small perturbation triggers a large response

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All in vivo experiments were performed according to the Protection of Animals Act, after approval of the German local authorities or the Institutional Animal Care and Use Committee (IA-CUC) of the University of Michigan, and the National Institutes of Health Guide for the Care and Use of Laboratory Animals (National Research Counsel, 2011), after approval from the University of Michigan IACUC or by the Local authorities responsible for the approval at Ghent University

Zannella, V