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50,51 Recent metabonomics retrospective studies had shown that increased plasma levels of BCAAs are associated with an increased risk of pancreatic cancer, which was validated in a genetically engineered mouse model of pancreatic ductal adenocarcinoma (PDAC)

AS: Data curation, Funding acquisition, Investigation, Validation, Writing review & editing

in Nature Medicine found that NNMT inhibition in white adipose tissue increased energy expenditure and reduced fat mass in animal models without altering food intake or physical activity (Kraus et al., Nature Medicine )