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A frequently observed prerequisite for the onset of cancer is genomic instability which is affected by aberrant methylation patterns of the genome (Negrini et al., 2010

Cellreplacement therapies Even though the very first experiments of cell transplantation in animal brains took place in 1890 (Thompson 1890), it was not until late 1970s in Sweden with the development of the 6-hydroxydopamine-lesioned rat model when neural grafting started gaining attention as a potential therapy for PD (Barker et al