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Because angiogenesis is a defining hallmark of tumor growth and metastatic progression, any therapeutic agent that enhances neovascularization could, in theory, facilitate tumor expansion and promote metastatic dissemination

Vitamin B12, folate, and the methionine remethylation cycle-biochemistry, pathways, and regulation

(2001) 280:G9229

* Correspondence: Vishwanath Venketaraman, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers