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Annexin A11 is a calcium-dependent phospholipid-binding protein, which is abundant in the nucleus [105]

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Silymarin (100 mg/kg) decreased cardiac fibrosis, collagen deposition, and dysfunction in diabetic mice, whereas silibinin used ERK1/2 MAPK signalling to control hypertrophic responses in cardiomyocytes ( 3.3.3 Renoprotective activity The oxidative and inflammatory burden to which the kidney is exposed is high due to its role in xenobiotic detoxification

That means consuming less refined sugar, saturated fat, alcohol, and caffeine and eating more whole grains and high-fiber foods