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CHAC1-mediated GSH degradation reduces S-glutathionylation of ARF6 at cysteine 90, thereby inactivating ARF6 and enhancing ferroptotic cell death ( Similarly, CHAC1 is upregulated in various kidney disease models ( CHAC1 upregulation was induced by cysteine and methionine deprivation, treatment with erastin and exposure to tunicamycin

Several studies support its efficacy in various organ systems affected during sepsis

Acute Myelogenous Leukemia (AML) Mesenchymal Stromal Cell (MSC) Have Distinct Protein Expression Patterns Compared to Normal MSC

Maisenbacher HW 3rd, Shroads AL 3rd, Zhong G, Daigle AD, Abdelmalak MM, Samper IS, et al