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Many patients assume their tiredness will resolve once they settle into their new weight and are surprised when it persists

Moreover, we defined Tyr phosphorylation motifs for 15 Ser/Thr kinases that displayed convergent Tyr phosphorylation activity, including known dual-specificity kinases in the WEE, LIMK and NEK families 22,23,24,25 , as well as new Ser/Thr kinases that we identified could also phosphorylate Tyr, including the mitophagy kinase PINK1, the cardiac kinase TNNI3K and the mitochondrial pyruvate dehydrogenase kinases (PDHKs) 20

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To overcome these barriers, future research must shift toward precision intervention that bypasses broad metabolic disruption in favor of selective molecular targeting