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Sleep and Immune System Recovery in Lyme During slow-wave sleep, natural killer (NK) cell activity increases, pro-inflammatory cytokines decline, and T-regulatory cells recalibrate immune tolerance

While this patient's diabetic nephropathy indicates underlying hyaline arteriosclerosis, his macrovascular lower extremity symptoms are caused by atherosclerosis

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At the cellular level, resistance evolves not only from genetic mutation but from adaptive programs involving stress responses, epigenetic plasticity, and lineage flexibility