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Multinational clinical study comparing isatuximab, carfilzomib and dexamethasone to carfilzomib and dexamethasone in relapse and/or refractory multiple myeloma patients (IKEMA)

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These findings contrast those of Dvl3 null mice, which displayed PCP defects in addition to loss of outer hair cells (Etheridge et al., Dvl3 null mice with one functional allele of Dvl2 exhibits more severe PCP defects than Dvl3 null animals alone, again suggesting Dvl members may complement each others

Acute kidney injury (AKI) : A subset of AKD characterized by kidney damage or dysfunction that occurs for seven days or less