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They provide potential benefits beyond skin whitening, including detoxification and enhanced immune function

Clinically, this condition presents with a characteristic saturation gapdiscordance between pulse oximetry and arterial co-oximetryalong with cyanosis and chocolate-brown blood discoloration, typically triggered by oxidative drugs such as dapsone, benzocaine, or nitrates

It's most often seen in people of African descent, though many people of Middle Eastern descent and a few people of European background may have it as well

Hum Reprod 29(10):21142122 Besong EE, Akhigbe TM, Ashonibare PJ, Oladipo AA, Obimma JN, Hamed MA, Adeyemi DH, Akhigbe RE (2023a) Zinc improves sexual performance and erectile function by preventing penile oxidative injury and upregulating circulating testosterone in lead-exposed rats