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The possible reason is that Ferr-1 can stabilize the intracellular iron pool, but has a limited effect on the uptake and transformation of iron ions, so TFR1 and DMT1, which transport iron into cells and affect the valence state of iron ions, have limited changes

Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascn S, Hatzios SK, Kagan VE, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat GC, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti FM, Torti SV, Toyokuni S, Woerpel KA, Zhang DD (2017) Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease

Chronic Illness Management 5.3.8

It is required by the enzyme "glutathione reductase," which is responsible for "recycling" glutathione back into its active, reduced form after it has neutralised a free radical