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Three trials were conducted in men (Reference Lecoultre, Carrel and Egli32,Reference Ohnaka, Ikeda and Maki38,Reference Superko, Bortz and Williams40) , three in women (Reference Ahmed Al-Naggar, Osman and Abdulghani23,Reference Cardoso, Salgado and Cesar28,Reference Mortazavi, Paknahad and Hasanzadeh34) and the remainder in either sex

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Thus, in accordance with experience and knowledge, the practicing physician can modify each protocol for the administration of a chemotherapeutic agent according to the individual patient's needs, as the treatment proceeds