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Since ROS played a critical role in sonodynamic therapy 34,35 , the intracellular ROS levels in G422 glioma cells incubated with R848-loaded BEAGA/ApoE-PDHD (BEAGA/ApoE-PDHD@R848), ILD-loaded BEAGA/ApoE-PDHD (BEAGA/ApoE-PDHD@ILD), and R848- and ILD- coloaded BEAGA/ApoE-PDHD (BEAGA/ApoE-PDHD@ILD & R848) under LFUS irradiation were analyzed by 2,7-dichlorofluorescin diacetate (DCFH-DA) assay

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