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SAM differentially regulates MAT isoforms: it sustains MAT1A expression but suppresses MAT2A, creating a negative feedback loop that limits excessive MAT2A-driven SAM production (181)

As a result, patients may feel the benefits sooner

Anticancer Res 1997

However, the relationships between concentrations and the pharmacokinetics (PK) of platinum and biomarkers of kidney injury have not been well elucidated