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Concurrently, PPIs, frequently prescribed to diabetic patients for gastroesophageal reflux disease management, impair protein-bound vitamin B12 release from dietary sources in the non-acidic gastric environment, with prolonged use ( 2 years) conferring a 65% increased risk of deficiency [159]

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In the present study, we unveiled that methionine-derived SAM is exploited for the synthesis of UQ to maintain the integrity of mitochondrial respiratory chain, thereby methionine deprivation suppresses the accumulation of intracellular ROS that are released from electron transfer