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The cysteinyl thiol is a potent reducing agent, making GSH the most abundant antioxidant intracellular small molecule thiol

Indeed, owing to the presence of the same conserved serine residue, GSTUs also possess glutathionylation activities toward herbicides, safeners and several other cyclic/aromatic compounds

Studies on a larger number of plant models, crops and growth conditions, especially those such as cadmium stress that affect glutathione availability, might help to further clarify whether and when DHARs fulfill a direct role in ascorbate recycling

In addition, NLRP3 inflammasome activation can disrupt tight junction proteins between EC, resulting in increased vascular permeability ( Figure 6 )