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In addition to the defensive mode, the intracellular L

Although research evidence from patient studies suggests a close association between disrupted energy metabolism and PD, it remains uncertain whether bioenergetic dysfunction precedes or results from neuronal degeneration

To test the Photostability upon laser irradiation, 200 L of PLGA nanoparticles encapsulating DDA-GSH-AuNCs, Nile red or fluorescein were placed in UV 96-Well microplate and irradiated with the following lasers: (364 nm, 80 mW, 248 mW/cm 2 ), (568 nm, 30 mW, 93 mW/cm 2 ) and (488 nm, 30 mW, 93 mW/cm 2 ), respectively using confocal laser scanning microscope (LSM 510 META, Carl Zeiss MicroImaging GmbH, Gttingen, Germany) for total duration of 20 minutes

This integrated model reveals the regulatory network from NLRP3 inflammasome activation and effector release to IL-1-mediated amplification of inflammatory cascades