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Glutathione S-transferases (GSTs) are a group of enzymes that catalyze the addition of glutathione to electrophilic target compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress [37,38], thus achieving a detoxification effect by eliminating toxins and carcinogens

Tobacco cigarette smoking induces cerebrovascular dysfunction followed by oxidative neuronal injury with the onset of cognitive impairment

In males, aspartame caused hepatocellular carcinoma, hepatocellular adenoma or carcinoma (combined), bronchioloalveolar carcinoma, bronchioloalveolar adenoma or carcinoma (combined), and a significant increase in the incidence of lymphoblastic leukaemia, of monocytic leukaemia, and of total myeloid tumours, was also reported

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