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Activated TBK1 regulates phosphorylation of transcription factors such as interferon (IFN) regulatory factor 3 (IRF3), interferon-regulatory factor 7 (IRF7), and NF-B, which then translocate into the cell nucleus to promote the secretion of type I IFNs and proinflammatory cytokines [5,6,7]

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We have reported previously successful treatment of a patient with 2009 H1N1 influenza virus pneumonia with N-acetylcysteine, administered as a 100 mg/kg continuous intravenous infusion daily for 3 days, with consequent suppression of fever and C-reactive protein concentration and corresponding clinical improvement.2 The C-reactive protein of this patient reduced from 183 mg/L to 11.7 mg/L and fraction of inspired oxygen requirement from 1.0 to 0.35

Int J Mol Sci 17(12):2140