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Annu Rev Plant Biol 57(1):1953 Kadotani N, Nakayashiki H, Tosa Y, Mayama S (2003) RNA silencing in the phyto-pathogenic fungus Magnaporthe oryzae

Notably, compound 1 has a novel 8/5/5 tricyclic ring structure, while compound 2 is the first 13-norguaiane-type sesquiterpenoid with a 5/7/5 tricyclic ring system

Syncytin-1, a protein known to activate pro-inflammatory pathways, has been identified as a trigger for these autoimmune cascades, amplifying immune responses against CNS tissues and exacerbating disease pathology [83]