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Local injections typically call for smaller amounts to achieve concentrated effects in a specific area, whereas systemic administration requires higher doses to account for broader distribution and clearance

Magnesium chloride injection: Package insert / prescribing info [Internet]

Patients should be counseled that periodic retreatment is likely to be necessary when symptoms recur

By delving into these factors, the review aims to deepen the understanding of the complex interplay of elements that lead to ACL injuries, thereby informing the development of more targeted and effective strategies for the prevention and treatment of these debilitating injuries