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The encapsulation of insulin or semaglutide in Bu-PEG NPs formed insulin-loaded Bu-PEG NPs (BU-NP@INS) and semaglutide-loaded Bu-PEG NPs (BU-NP@Sema), significantly enhancing the oral bioavailability and hypoglycemic function of INS and Sema [85, 86]

Case Study: The low uric acid (LUA) Dalmatian A tragic example: Up to 2011, all AKC-registered Dalmatians reportedly carried a mutated version of the SLC2A9 gene, which causes exceedingly high levels of uric acid - about ten times that of a normal dog