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doi: 10.1126/science.aal3222 108 GouillyD.Saint-AubertL.RibeiroM

[Abstract] Pathogens

Hypothetically, for a patient with AS who has active sacroiliitis and subclinical colitis on biopsy, a biologically rational, though untested, regimen could pair a systemic biologic (such as a TNF or IL-17A inhibitor to suppress inflammation) with a gut-focused therapy (such as a probiotic or even FMT to restore microbiota and mucosal integrity)