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Peroxynitrite ions can change oocyte spindle shape and chromosomal organization in a dose-dependent way (99)

The 1mg arm was a fixed low-dose cohort with no escalation

A total of 221 subjects (37 males and 184 females) diagnosed by experienced neurologists as migraineurs according to the International Classification of Headache Disorders criteria (ICHD-3), aged between 18 and 72 years (mean standard deviation: 41.9 11.3 years), served as case group