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*Correspondence: Zhenjie Liu, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Biosafety and Biosecurity, a section of the journal Frontiers in Bioengineering and Biotechnology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

doi:10.1001/jamanetworkopen.2020.31846

Current literature also highlights the eminent role of cancer stem cell population in tumors to promote metastatic processes (Steinbichler et al

Risk factors include: Celiac disease Pancreatic insufficiency Gallbladder or bile flow problems Cholestatic liver disease Cystic fibrosis Short bowel syndrome Bariatric surgery Chronic diarrhea Very low-fat diets If a patient has neuropathy, ataxia, balance problems, and evidence of fat malabsorption, vitamin E should be checked