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Porphyrin accumulation, protein aggregation, autophagic vacuoles, mitochondria morphology, single cell spatial transcriptomics, mRNA expression, and mass-to-charge ratios of heme enzymes were assessed

DHA not only reduces GSH to GSSG but also inactivates GPX4 directly, facilitating LPO accumulation and cell ferroptosis collaboratively (Figure 5E)

You might hear about taking over-the-counter painkillers such as acetaminophen (Tylenol) or ibuprofen (Advil) as a preventive approach, but this has not been studied