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However, when ferroptosis inhibitors were added, the degree of myocardial injury was significantly reduced in rats, and the levels of ROS, intracellular Fe 2+ concentration, ACSL 4 , ATF 4 and CHOP decreased, indicating that ferroptosis inhibitors can improve diabetic myocardial injury by reducing ERS (72)

Together, T cells, macrophages, and cytotoxic T cells produce cytotoxic cytokines and prostaglandins that cause joint inflammation, synovial proliferation, and bone and cartilage destruction

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