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In subunit 2 the domain I helices are dark cyan -strands are orange, and the domain II helices are light cyan

The transfected cells were then cultured in medium containing puromycin (5 g ml 1 ) for 10 days

Silymarin shows various biological activities in scientific investigations that are currently being further researched: Antioxidant: Protects cells against oxidative stress caused by free radicals Hepatoprotective: Under experimental conditions, silymarin can inhibit the binding of certain liver toxins to liver cells and support the regenerative capacity of hepatocytes Anti-inflammatory: Anti-inflammatory properties demonstrated in cell models Cholagogue: Possible support for bile production and bile flow Lipid profile: Influence on cholesterol and fat metabolism parameters in clinical studies Immunomodulatory: Activity in the immune system demonstrated in animal models Milk Thistle and the Liver Supporting liver health is the most thoroughly researched area of application for milk thistle extract

Conclusion: This study combined network pharmacology and molecular docking to predict the underlying mechanism of Loganin against PMOP, validated by the in vivo mouse model showing that Loganin attenuated OVX-induced bone loss by inhibiting inflammation