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Indeed, co-treatment with AZ67, a selective PFKFB3 inhibitor, significantly reversed the enhanced cell death of roxadustat treated neurons exposed to OGD (Figure 8E)

This lack of data presents a significant obstacle to designing truly personalized nanomaterial-based treatments

However, this review also noted that the quality of the studies was not very high, so more studies are needed before its possible to make any firm recommendations

doi: 10.1136/jnis-2025-023389 Karthik Seetharam , Aditya Patel , Harshith Thyagaturu , Gabriel Lora Ferreira , Salma Zook , Katelyn Ingram , Jilan Shah , Divya Situt , Natalie Vitiello , Parvez Mir , Mahwash Kassi