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Circulation 112 (24), 36973706

Investigations are guided by clinical suspicion rather than routine panels: for example, thyroid function tests and ferritin may be checked if symptoms suggest deficiency or thyroid disease, while an androgen profile may be appropriate in women presenting with menstrual irregularity, hirsutism, or acne

Moreover, alterations in the levels of the membrane phospholipid phosphatidylinositol 4,5 bisphosphate (PIP 2 ) can regulate GIRK channel activity (Wang et al., 2014