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Keywords Alzheimer's disease, GHK-Cu, 5xFAD transgenic mouse, intranasal administration, amyloid plaques, neuroinflammation Introduction Alzheimer's disease (AD) is a complex disease that was the seventh leading cause of mortality in the US in 2022 [1]

Notwithstanding the strides achieved in genetic manipulation and regenerative technologies, L-DOPA or compounds related to dopamine metabolism such as MAO-B inhibitors remain as the major modes of palliative care for PD patients 39,56

Between these extremes lies a narrow zone of mechanical balance, where stress is efficiently translated into ventilation with minimal strain energy loss