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Embodiment A67 (a further embodiment of Embodiment A1) provides a compound selected from: (2R)-2-(5-chloro-2-methoxypyridin-4-yl)-1-[7-methyl-6-(2-methyl-2H-tetrazol-5-yl)-3,4-dihydro-1H-spiro[1,8-naphthyridine-2,3-pyrrolidin]-1-yl]propan-1-one, DIAST-1

Toll-like receptor 4 from the receptor presenting gut cells is activated by microbial agents

According to Anktar et al., (1990), M

Importantly, no serious complicationssuch as endometriosis, ovarian malignancies, or autoimmune diseaseswere reported, suggesting that autologous MenSC transplantation represents a safe and promising approach for improving reproductive outcomes in women with ovarian insufficiency (Table 1)