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Immunofluorescence and Structured Illumination Microscopy Cells (typically 20,000) were grown on coverslips and after the indicated treatment fixed with formalin

Amylin analogs like cagrilintide appear to act via hindbrain satiety circuits and may also influence reward-related pathways involving AgRP and POMC neurons

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This multi-pathway activity resembles what we see with other biologic treatments in orthopedic surgery, where the therapeutic effect comes from coordinated biological response rather than a single drug-receptor interaction