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To regenerate more reduced equivalents of NADPH, LPS-activated Ms upregulate NADPH-generating pathways, including glucose-6-phosphate dehydrogenase (G6PD), which is the rate limiting enzyme of the PPP (2, 49, 50)

Protein pellets were dried and then resuspended in either 47.5 l (control) or 87.5 l (AD) of 50% trifluoroethanol (TFE) in 50 mM ammonium bicarbonate (ABC)

Severe deterioration in the boys condition with signs of stroke and weakness with abnormal reflexes on the left side were also reported [33]

NAD+ supports energy production in cells, while glutathione helps neutralize the resulting oxidative byproducts