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Journal of Cosmetic Dermatology 20(9):2793-2803

Skoog I, Wallin A, Fredman P, Hesse C, Aevarsson O, Karlsson I, Gottfries CG, Blennow K (1998) A population study on blood-brain barrier function in 85-year-olds: relation to Alzheimers disease and vascular dementia

Manifestations include tingling and numb extremities, motor disturbances such as abnormalities of gait, and cognitive changes that range from memory loss and depression to frank dementia, with or without mood changes (Goodman & Salt, 1990)