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Common signs of nicotine addiction include intense cravings, irritability, difficulty concentrating, continued use even when health issues arise, and physical dependence marked by withdrawal symptoms such as headaches, insomnia, and mood swings when nicotine use is reduced or stopped

Adapted from figure 4.1 in: How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable disease: A Report of the Surgeon General.(6) The pharmacokinetic profile for MESH is very similar to the profile created by smoking a cigarette and the study subjects preferred e-cigarette

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Trends in the epidemiology of head and neck cancer in London Clinical Otolaryngology