The model describes a positive feedback (more cytotoxicity releases more auto-antigens) and a negative one (cytotoxicity stimulates immunoregulatory T Reg )
Meanwhile, the reduction of beneficial bacteria (e.g., Bifidobacterium) results in insufficient production of short-chain fatty acids (SCFAs), which not only weakens their anti-inflammatory effects but also loses the inhibitory regulation on glycolysis, further breaking the balance (51, 52)
Its a step towards better well-being
DIG exhibited higher positive signal intensity compared to sICIs across the following PTs: myocarditis (ROR 2.221, IC 025 0.486, PT: 10028606), immune-mediated myocarditis (ROR 2.922, IC 025 0.610, PT: 10082606), adrenal insufficiency (ROR 2.503, IC 025 0.602, PT: 10001367), hyperthyroidism (ROR 1.872, IC 025 0.305, PT: 10020850), thyroiditis (ROR 2.669, IC 025 0.546, PT: 10043778), immune-mediated enterocolitis (ROR 3.948, IC 025 0.937, PT: 10078961), pyrexia (ROR 1.570, IC 025 0.290, PT: 10037660), hepatic function abnormality (ROR 2.582, IC 025 0.591, PT: 10019670), hepatitis (ROR 2.705, IC 025 0.637, PT: 10019717), liver disorder (ROR 2.718, IC 025 0.646, PT: 10024670), immune-mediated hepatitis (ROR 5.504, IC 025 0.994, PT: 10078962), immune-mediated liver disorder (ROR 5.322, IC 025 0.966, PT: 10083521), cytokine release syndrome (ROR 7.650, IC 025 1.103, PT: 10052015), autoimmune diseases (ROR 1.754, IC 025 0.275, PT: 10061664), sepsis (ROR 1.414, IC 025 0.062, PT: 10040047), diabetic ketoacidosis (ROR 2.294, IC 025 0.472, PT: 10012671), type 1 diabetes mellitus (ROR 2.421, IC 025 0.508, PT: 10067584), arthritis (ROR 1.562, IC 025 0.113, PT: 10003246), myositis (ROR 2.204, IC 025 0.412, PT: 10028653), and acute kidney injury (ROR 1.708, IC 025 0.264, PT: 10069339)
